Brain-Specific Superoxide Dismutase 2 Deficiency Causes Perinatal Death with Spongiform Encephalopathy in Mice

Figure 3

Gliosis was detected in the cortex of B-Sod2^−/−. Coronal sections of the brains from three-week-old control (a, b) and B-Sod2^−/− (d, e) with hematoxylin and eosin staining. Higher power views (inset) showed neuronal vacuolization in B-Sod2^−/− (e) but not in control (b). Immunohistochemical staining of sections with anti-GFAP antibody (c and f) revealed enhanced gliosis in B-Sod2^−/− (f) but not in control (c). The scale bars indicate 200 μm.

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