Inhibition of Adenylyl Cyclase Type 5 Increases Longevity and Healthful Aging through Oxidative Stress Protection

Table 1

Longevity and oxidative stress resistance.

Longevity models related to oxidative stress resistance	Longevity models not related to oxidative stress resistance	Longevity models with relationship to oxidative stress resistance controversial or not studied
AC5 KO [3–6]	Gpx4 +/− KO [28]	Ames dwarf [29–31]
Caloric restriction [8, 32–35]	GHR/BP KO [36, 37]	FIRKO [38, 39]
Snell dwarf [40–42]	MIF KO [43, 44]	PAPPA^−/− KO [45, 46]
GHR KO [9, 40]	α MUPA OE [47, 48]	RIIβ−/− KO [49]
Igf-1r^+/− KO [10, 50, 51]		S6K1−/− KO [52, 53]
Klotho OE [11, 12, 54]		Hct-UCP2 OE [55]
p66^shc−/− [13, 56]		PEPCK-C OE [57]
TRX OE [14, 58]		PtenTg [59]
MCAT [15, 60–62]		SIRT6 Tg [63]
MT OE [16]
Agtr1 α−/− KO [17]
Irs1−/− KO [18]
R6/2 Irs2+/− IRS2 Btg KO [19]
Surf1−/− KO [21, 22, 64]
Mclk1+/− KO [65, 66]

Data are shown as mice models followed by the supporting bibliography in parenthesis .