Physical Training Regulates Mitochondrial Parameters and Neuroinflammatory Mechanisms in an Experimental Model of Parkinson’s Disease

Figure 4

The effects of two physical training protocols on TNF-α (a and b), IFN-γ (c and d), IL-17 (e and f), IL-1β (g and h), and TGF-β (i and j) levels in the striatum and hippocampus of mice exposed to 6-OHDA. Protein levels of these cytokines were assayed using ELISA kits. Values are expressed as mean ± SEM (). , Sham versus U + 6-OHDA; , U + 6-OHDA versus training groups plus 6-OHDA. Untrained + vehicle (Sham), strength training + vehicle (STR), treadmill training + vehicle (TTR), untrained + 6-OHDA (U + 6-OHDA), strength training + 6-OHDA (STR + 6-OHDA), and treadmill training + 6-OHDA (TTR + 6-OHDA).

(a) Striatum

(b) Hippocampus

(c) Striatum

(d) Hippocampus

(e) Striatum

(f) Hippocampus

(g) Striatum

(h) Hippocampus

(i) Striatum

(j) Hippocampus