Regulation of System by Pharmacological Manipulation of Cellular Thiols

Figure 2

DEM induced increase in ¹⁴C-cystine uptake is mediated by system . Cultures were exposed to 100 μM DEM for 40 min, 6 hrs, or 24 hrs, after thorough washing, ¹⁴C-cystine uptake was measured for 20 minutes with or without the system inhibitor sulfasalazine (SSZ) present. Results are expressed as mean + SEM ( = 8–16) after normalizing to untreated control uptake. indicates significant difference from control; < 0.05.