Regulation of System by Pharmacological Manipulation of Cellular Thiols

Figure 6

DEM causes an early decrease in cellular cysteine levels, while BSO causes an early and late increase in cellular cysteine levels. Cultures were exposed to varying concentrations of DEM or BSO for (a) 6 hrs or (b) 24 hrs, after which cellular cysteine levels were determined by HPLC. Bars show % cellular cysteine normalized to control (mean + SEM, = 8). indicates significant difference from control < 0.05.

(a) 6 hours

(b) 24 hours