Efficacy of N-Acetylcysteine, Glutathione, and Ascorbic Acid in Acute Toxicity of Paraoxon to Wistar Rats: Survival Study

Figure 2

Cumulative relative risk of death over time with pretreatment of compounds. Cumulative relative risk (RR) of death over time with pretreatment, intraperitoneal injections of antioxidants followed by i.p. administration of POX and PAM. The legends on the side are depicting the treatment groups. RR was estimated by Cox [23] analysis, adjusted for POX dose (high/low) for each of the time points examined (30 min, after 30 min, 1, 2, 3, 4, 24, and 48 h). Best protection was conferred by PAM pretreatment only followed by GSH pretreatment. Efficacy of PAM was estimated to decrement when administered with antioxidants. B/F denotes before.