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Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 359740, 11 pages
http://dx.doi.org/10.1155/2015/359740
Research Article

Novel Antioxidant Tripeptide “ACQ” Can Prevent UV-Induced Cell Death and Preserve the Number of Epidermal Stem Cells

Department of Dermatology, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea

Received 2 April 2015; Accepted 8 June 2015

Academic Editor: Tullia Maraldi

Copyright © 2015 Hye-Ryung Choi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. M. Watt and H. Fujiwara, “Cell-extracellular matrix interactions in normal and diseased skin,” Cold Spring Harbor Perspectives in Biology, vol. 3, no. 4, pp. 1–14, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Breitkreutz, I. Koxholt, K. Thiemann, and R. Nischt, “Skin basement membrane: the foundation of epidermal integrity—BM functions and diverse roles of bridging molecules nidogen and perlecan,” BioMed Research International, vol. 2013, Article ID 179784, 16 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. M. F. Brizzi, G. Tarone, and P. Defilippi, “Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche,” Current Opinion in Cell Biology, vol. 24, no. 5, pp. 645–651, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. D. T. Scadden, “The stem-cell niche as an entity of action,” Nature, vol. 441, no. 7097, pp. 1075–1079, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. H.-R. Choi, Y.-A. Kang, J.-W. Shin, J.-I. Na, C.-H. Huh, and K.-C. Park, “Redox status is critical for stemness in skin equivalents,” Oxidative Medicine and Cellular Longevity, vol. 2012, Article ID 819623, 7 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. A.-R. Ji, S.-Y. Ku, M. S. Cho et al., “Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage,” Experimental and Molecular Medicine, vol. 42, no. 3, pp. 175–186, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Park, H.-H. Park, H. Choi et al., “Coenzyme Q10 protects neural stem cells against hypoxia by enhancing survival signals,” Brain Research, vol. 1478, pp. 64–73, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. D.-S. Kim, H.-J. Cho, H.-R. Choi, S.-B. Kwon, and K.-C. Park, “Isolation of human epidermal stem cells by adherence and the reconstruction of skin equivalents,” Cellular and Molecular Life Sciences, vol. 61, no. 21, pp. 2774–2781, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Cabiscol, J. Tamarit, and J. Ros, “Oxidative stress in bacteria and protein damage by reactive oxygen species,” International Microbiology, vol. 3, no. 1, pp. 3–8, 2000. View at Google Scholar · View at Scopus
  10. B. Halliwell, “Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment,” Drugs and Aging, vol. 18, no. 9, pp. 685–716, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Pompella, A. Visvikis, A. Paolicchi, V. de Tata, and A. F. Casini, “The changing faces of glutathione, a cellular protagonist,” Biochemical Pharmacology, vol. 66, no. 8, pp. 1499–1503, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. D. A. Dickinson and H. J. Forman, “Cellular glutathione and thiols metabolism,” Biochemical Pharmacology, vol. 64, no. 5-6, pp. 1019–1026, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Dernbach, C. Urbich, R. P. Brandes, W. K. Hofmann, A. M. Zeiher, and S. Dimmeler, “Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress,” Blood, vol. 104, no. 12, pp. 3591–3597, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. W. J. Carr, R. E. Oberley-Deegan, Y. Zhang, C. C. Oberley, L. W. Oberley, and M. Dunnwald, “Antioxidant proteins and reactive oxygen species are decreased in a murine epidermal side population with stem cell-like characteristics,” Histochemistry and Cell Biology, vol. 135, no. 3, pp. 293–304, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Kaur, “Interfollicular epidermal stem cells: identification, challenges, potential,” Journal of Investigative Dermatology, vol. 126, no. 7, pp. 1450–1458, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. F. Wang, X. Xu, X. Fan et al., “A cell-penetrating peptide suppresses inflammation by inhibiting NF-κB signaling,” Molecular Therapy, vol. 19, no. 10, pp. 1849–1857, 2011. View at Publisher · View at Google Scholar
  17. F. M. Watt and R. R. Driskell, “The therapeutic potential of stem cells,” Philosophical Transactions of the Royal Society of London B: Biological Sciences, vol. 365, no. 1537, pp. 155–163, 2010. View at Publisher · View at Google Scholar
  18. H. Choi, “Niche interactions in epidermal stem cells,” World Journal of Stem Cells, vol. 7, no. 2, pp. 495–501, 2015. View at Publisher · View at Google Scholar
  19. P. H. Jones, S. Harper, and F. M. Watt, “Stem cell patterning and fate in human epidermis,” Cell, vol. 80, no. 1, pp. 83–93, 1995. View at Publisher · View at Google Scholar · View at Scopus
  20. H.-J. Cho, I.-H. Bae, H.-J. Chung et al., “Effects of hair follicle dermal sheath cells in the reconstruction of skin equivalents,” Journal of Dermatological Science, vol. 35, no. 1, pp. 74–77, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. D.-S. Kim, H.-J. Cho, S.-K. Yang, J.-W. Shin, C.-H. Huh, and K.-C. Park, “Insulin-like growth factor-binding protein contributes to the proliferation of less proliferative cells in forming skin equivalents,” Tissue Engineering, Part A, vol. 15, no. 5, pp. 1075–1080, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. Upton, L. Cuttle, A. Noble et al., “Vitronectin: growth factor complexes hold potential as a wound therapy approach,” Journal of Investigative Dermatology, vol. 128, no. 6, pp. 1535–1544, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. T. L. Fernandez, D. R. van Lonkhuyzen, R. A. Dawson, M. G. Kimlin, and Z. Upton, “Insulin-like growth factor-I and UVB photoprotection in human keratinocytes,” Experimental Dermatology, vol. 24, no. 3, pp. 235–238, 2015. View at Publisher · View at Google Scholar
  24. R. D. Evans, V. C. Perkins, A. Henry, P. E. Stephens, M. K. Robinson, and F. M. Watt, “A tumor-associated beta1 integrin mutation that abrogates epithelial differentiation control,” Journal of Cell Biology, vol. 160, no. 4, pp. 589–596, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. A. J. Zhu, I. Haase, and F. M. Watt, “Signaling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 12, pp. 6728–6733, 1999. View at Publisher · View at Google Scholar · View at Scopus