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Oxidative Medicine and Cellular Longevity
Volume 2015, Article ID 437381, 11 pages
http://dx.doi.org/10.1155/2015/437381
Research Article

Isoflavones Reduce Copper with Minimal Impact on Iron In Vitro

1Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
2Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
3Faculty of Pharmacy, University of Porto, Praça Gomes Teixeira, 4099-002 Porto, Portugal

Received 23 February 2015; Revised 17 June 2015; Accepted 18 June 2015

Academic Editor: Michal Wozniak

Copyright © 2015 Jana Karlíčková et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary materials include comparison of iron and copper chelating activity of tested isoflavones by use of 95% prediction bands (S1,2), comparison of isoflavones by means of confidence intervals of linear regression lines of the relationship between copper reduction and the ratio isoflavone to copper at pH 7.5 (S3), and assessment of genistein-ferric and genistein-cupric ions complex stoichiometry by the use of Job’s method (S4, 5, 6).

  1. Supplementary Materials