Renal Oxidative Stress Induced by Long-Term Hyperuricemia Alters Mitochondrial Function and Maintains Systemic Hypertension

Table 1

Functional and mitochondria data in long-term follow-up groups.

Parameter	Vehicle	OA	OA + Tempol	OA + AP
Plasma UA (mol/L)	44 ± 2	110 ± 27^a	117 ± 36^a	26 ± 6^b
Systolic blood pressure (mmHg)	125 ± 4	144 ± 7^a	121 ± 5^b	129 ± 8^b
RPF (mL/min)	3.7 ± 0.3	2.7 ± 0.4^a	4.4 ± 0.3^ab	4.1 ± 0.3^b
RVR (mmHg/mL/min)	19 ± 1	28 ± 5^a	15 ± 1^b	17 ± 3^b
	Mitochondrial respiration malate/glutamate
State 3 (ng AtO2/min/mg prot)	83 ± 18	43 ± 13^a	149 ± 44^ab	114 ± 43^b
State 4 (ng AtO2/min/mg prot)	34 ± 6^c	30 ± 11^c	57 ± 21	37 ± 5^c
	Mitochondrial respiration succinate/rotenone
State 3 (ng AtO2/min/mg prot)	170 ± 60	84 ± 36^a	238 ± 53^b	237 ± 60^b
State 4 (ng AtO2/min/mg prot)	70 ± 20	53 ± 25	87 ± 20^b	65 ± 14

Data are expressed as mean ± SD. RPF = renal plasma flow; RVR = renal vascular resistance. ^a < 0.05 versus control; ^b < 0.05 versus OA; ^c < 0.05 versus Tempol.