Hyperhomocysteinemia and MTHFR Polymorphisms as Antenatal Risk Factors of White Matter Abnormalities in Two Cohorts of Late Preterm and Full Term Newborns

Table 4

Linear regression model showed dependence of WMA from tHcy levels, GA, Apgar scores at 1 and 5 minutes, 1298AC, and 677CT/1298AC MTHFR genotypes. IVH resulted in being dependent on GA and bradycardia by the same model.

WMA	values
tHcy	0.014^*
GA	0.000^*
Apgar 1	0.000^*
Apgar 5	0.000^*
Altered flussimetry	0.999
Preeclampsia	0.999
PROM	0.096
677CT	0.297
677TT	0.065
1298AC	0.000^*
1298CC	0.270
677CT/1298AC	0.000^*
IVH
tHcy	0.862
GA	0.000^*
Preeclampsia	0.314
PROM	0.138
Altered flussimetry	0.410
Bradycardia	0.000^*
677CT	0.726
677TT	0.522
1298AC	0.101
1298CC	0.999
677CT/1298AC	0.390

Statistical significance. . tHcy: total homocysteine; MTHFR: methylenetetrahydrofolate reductase; WMA: white matter abnormalities; IVH: intraventricular hemorrhage; PROM: premature rupture of membranes; BW: birth weight; GA: gestational age; PFO: patent foramen ovale; CT and TT: heterozygous and homozygous MTHFR 677 genotypes; AC and CC: heterozygous and homozygous MTHFR 1298 genotypes.