Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma
Table 3
The distribution of genotypes in control subjects and patients with EH, EH + ECa, and ECa.
Genes and genotypes
Controls number (%)
EH
mult OR (95% CI)
EH + ECa
mult OR (95% CI)
ECa
mult OR (95% CI)
Number (%)
crude OR (95% CI)
Number (%)
crude OR (95% CI)
Number (%)
crude OR (95% CI)
COMT rs4680 G1947A Val158Met
HWE
HWE
HWE
HWE
A/A
273 (25.4)
26 (30.2)
0.33 (dom)
0.30 (dom)
17 (23.3)
0.68 (dom)
0.68 (dom)
44 (25.9)
0.75 (add)
0.74 (add)
G/A
559 (52.0)
39 (45.4)
0.79
0.77
39 (53.4)
1.12
1.13
90 (52.9)
0.96
0.96
G/G
242 (22.5)
21 (24.4)
(0.49–1.27)
(0.47–1.25)
17 (23.3)
(0.64–1.97)
(0.63–2.04)
36 (21.2)
(0.76–1.22)
(0.73–1.25)
HFE rs1800562 G845A Cys282Tyr
HWE
HWE
HWE
HWE
G/G
1045 (94.5)
84 (94.4)
0.97 (dom)
0.98 (dom)
71 (93.4)
0.70 (dom)
0.91 (dom)
174 (93.5)
0.48 (add)
0.56 (add)
G/A
60 (5.4)
5 (5.6)
1.02
1.01
5 (6.6)
1.21
1.06
11 (5.9)
1.25
1.22
A/A
1 (0.1)
0 (0.0)
(0.40–2.61)
(0.39–2.60)
0 (0.0)
(0.48–3.10)
(0.39–2.89)
1 (0.5)
(0.69–2.27)
(0.63–2.35)
HFE rs1799945 C187G His63Asp
HWE
HWE
HWE
HWE
C/C
783 (70.9)
62 (69.7)
0.32 (add)
0.36 (add)
57 (75.0)
0.28 (add)
0.32 (add)
149 (80.1)
0.015 (dom)
0.024 (dom)
C/G
298 (27.0)
21 (23.6)
1.23
1.21
19 (25.0)
0.76
0.77
30 (16.1)
0.60
0.62
G/G
24 (2.2)
6 (6.7)
(0.83–1.82)
(0.81–1.80)
0 (0.0)
(0.46–1.26)
(0.46–1.30)
7 (3.8)
(0.41–0.89)
(0.41–0.95)
APOE rs7412 C526T Arg158Cys E2 allele (158Cys)
HWE
HWE
HWE
HWE
C/C
913 (85.7)
73 (82.0)
0.35 (dom)
0.36 (dom)
50 (65.8)
(dom)#
0.0012 (dom)##
149 (84.2)
0.59 (dom)
0.64 (dom)
C/T
144 (13.5)
16 (18.0)
1.32
1.32
25 (32.9)
3.12
2.58
27 (15.2)
1.13
1.13
T/T
8 (0.8)
0 (0.0)
(0.75–2.32)
(0.74–2.33)
1 (1.3)
(1.89–5.17)
(1.49–4.45)
1 (0.6)
(0.73–1.75)
(0.68–1.86)
APOE rs429358 T388C Cys112Arg E4 allele (112 Arg)
HWE
HWE
HWE
HWE
T/T
827 (77.7)
60 (67.4)
0.034 (dom)
0.026 (dom)
57 (75.0)
0.60 (dom)
0.38 (dom)
140 (79.1)
0.56 (add)
0.69 (add)
T/C
218 (20.5)
28 (31.5)
1.68
1.73
18 (23.7)
1.16
1.29
35 (19.8)
0.90
0.92
C/C
20 (1.9)
1 (1.1)
(1.05–2.68)
(1.08–2.77)
1 (1.3)
(0.68–1.99)
(0.73–2.28)
2 (1.1)
(0.63–1.28)
(0.62–1.37)
Rs number is a reference SNP ID number in The Single Nucleotide Polymorphism database, dbSNP. The choice of each genetic model was based on AIC value. The genetic model: rec, recessive; dom, dominant; add, additive. OR, odds ratio; CI, confidence interval; mult, multivariate. In multivariate analysis we adjusted for age, BMI, hypertension, diabetes, smoking habits, and using of HRT. Significant results are in bold. Bonferroni adjusted values for significant results ; ; ; ; ; .
