Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma

Table 6

The distribution of the APOE E 3/E 3 reference and variant (including E 2 and E 4 alleles) genotypes in control subjects and patients with EH, EH + ECa, and ECa.

APOE genotypes		Controls number (%)	EH		EH + ECa		ECa
			Number (%)	mult; OR (95% CI)	Number (%)	mult; OR (95% CI)	Number (%)	mult OR; (95% CI)
rs7412 + rs429358				0.038		0.004		0.87
	E 3/E 3	695 (65.26)	48 (53.93)	1.60	37 (48.68)	1.98	114 (64.41)	1.04
	Other	370 (34.74)	41 (46.07)	(1.04–2.47)	39 (51.32)	(1.24–3.15)	63 (35.39)	(0.75–1.45)

APOE E 3 allele, 112Cys, and 158Arg; other, any genotypes with 112Arg and/or 158Cys.
OR, odds ratio; CI, confidence interval; mult, multivariate.
In multivariate analysis we adjusted for age, BMI, hypertension, diabetes, smoking habits, and using of HRT. Significant results are in bold.
Bonferroni adjusted values ; .