Research Article

Association of the Apolipoprotein E 2 Allele with Concurrent Occurrence of Endometrial Hyperplasia and Endometrial Carcinoma

Table 7

Haplotype-based analysis of the HFE gene polymorphisms in EH, EH + ECa, and ECa.

rs1800562
G845A
rs1799945
C187G
Controls
frequency (%)
EH ()EH + ECa ()EC ()
Frequency (%)P mult
OR (95% CI)
Frequency (%)P mult
OR (95% CI)
Frequency (%)P mult
OR (95% CI)

1GC0.81540.7928Reference0.8421Reference0.8468Reference
2GG0.15660.17910.35
1.21 (0.81–1.80)
0.1250.33
0.77 (0.45–1.30)
0.11830.15
0.77 (0.53–1.10)
3AC0.0280.02180.97
1.02 (0.40–2.58)
0.03290.98
0.99 (0.38–2.59)
0.03490.62
1.18 (0.61–2.28)

OR, odds ratio; CI, confidence interval; mult, multivariate.
The number of subjects with both genotyped SNPs. Subjects with missing genotyping data for one of the SNPs were not included in the haplotype-based analysis.
In multivariate analysis we adjusted for age, BMI, hypertension, diabetes, smoking habits, and using of HRT.