Hsp20 Protects against Oxygen-Glucose Deprivation/Reperfusion-Induced Golgi Fragmentation and Apoptosis through Fas/FasL Pathway

Figure 5

Hsp20 decreases FasL and Bax expression and inhibits caspases 3 and p115 cleavage in N2a cells exposed to OGDR. The experiment was repeated independently for at least three times. (a) Effects of Hsp20 on apoptotic proteins expression and p115 cleavage in N2a Cells treated with OGD 4 h plus 12 h reperfusion. Transfection with Hsp20 decreased FasL and Bax expression and inhibited caspases 3 and p115 cleavage after 12 h reperfusion following 4 h OGD. (b) Quantitation (mean ± SEM) of (a) from three independent experiments. Values are expressed as mean ± SEM. compared to N2a Cells treated with OGD 4 h plus 12 h reperfusion. compared to N2a Cells treated with OGD 4 h plus 12 h reperfusion.

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