Review Article

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

Figure 1

Balance between mediators of oxidative stress/inflammation and antioxidants/anti-inflammatory mediators. In a healthy organism mediators of oxidative stress and inflammation are in balance with the counteracting detoxifying and anti-inflammatory molecules. During disease this balance is shifted towards the oxidative stress and proinflammatory site, leading to DNA and protein damage, inflammation, and finally cell death.