OGG1 Involvement in High Glucose-Mediated Enhancement of Bupivacaine-Induced Oxidative DNA Damage in SH-SY5Y Cells

Figure 6

The effect of high glucose or bupivacaine on 8-oxodG expression and DNA damage. Con: SH-SY5Y cells of group control. HG: SH-SY5Y cells were exposed to 50 mM glucose for 8 d. Bup: SH-SY5Y cells were treated with 1.5 mM bupivacaine for 24 h. HG + Bup: SH-SY5Y cells were incubated with 50 mM glucose for 8 d and then treated with 1.5 mM bupivacaine for 24 h. (a) High glucose enhanced 8-oxodG expression induced by bupivacaine. (b) High glucose aggravated DNA damage induced by bupivacaine. (c) Summarized data show 8-oxodG expression as measured by the mean fluorescence intensity and DNA damage as detected by Olive tail moment. Data are presented as mean ± SD (), .

(a)

(b)

(c)