Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease

<div>CKD upregulates myostatin expression and decreases the phosphorylation of PI3K, Akt, and FoxO3a in rat muscle. (a) Upper: representative immunoblotting of Myostatin, p-PI3K, PI3K, p-Akt, Akt, p-FoxO3a, FoxO3a, and GAPDH. Middle and Lower: The ratio of p-PI3K, p-Akt, and p-FoxO3a and PI3K, Akt, and FoxO3a normalized to the sham group. (b) Immunohistochemical staining for Myostatin in TA muscle. Scale bar = 50 <i>μ</i>m. Values were described means, with SD represented by vertical bars. 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease 