Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity / 2015 / Article
Special Issue

Oxidative Stress-Mediated Reperfusion Injury 2014

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Editorial | Open Access

Volume 2015 |Article ID 689416 | https://doi.org/10.1155/2015/689416

Zhengyuan Xia, Yanfang Chen, Qian Fan, Mengzhou Xue, Ke-xuan Liu, "Oxidative Stress-Mediated Reperfusion Injury 2014", Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 689416, 2 pages, 2015. https://doi.org/10.1155/2015/689416

Oxidative Stress-Mediated Reperfusion Injury 2014

Received15 Apr 2015
Accepted15 Apr 2015
Published22 Jul 2015

Ischemia/reperfusion injury (IRI) and organ failure especially IRI-induced remote and multiple organ failure contribute significantly to postoperative mortality and morbidity, and reperfusion induced oxidative stress plays a critical role in this pathology [1, 2].

Reactive oxygen species (ROS) induced vascular endothelial dysfunction plays an important role in the development of IRI in various organs. In this special issue, Q. Yang et al. reported that the otherwise cardiac protective polymerized hemoglobin, when used at high dose, failed to alleviate cardiac IRI due to induction of oxidative damage in coronary artery. On the other hand, natural herbal extracts such as Licochalcone B as reported by J. Han et al. in this special issue conferred protection against myocardial IRI through attenuating ischemia-reperfusion induced oxidative damage.

The intravenous anesthetic propofol possesses antioxidant capacity and has been shown to attenuate IRI in patients undergoing cardiac surgery and in animal models of myocardial [3] and intestinal IRI [4]. In this special issue, X. Gan et al. further identified that propofol attenuated intestinal IRI through inhibiting the ROS generating NADPH oxidase mediated mast cell activation. Given that mast cell activation has been shown to play an important role in IRI-induced remote organ injury [5], the finding by X. Gan et al. may promote further in-depth studies, both experimental and clinical, regarding the potential protective effects of propofol in attenuating or preventing postischemic remote organ injuries.

Disturbances of mitochondrial homeostasis play critical roles in Acute Organ Failure [6] and in postischemic cellular injury [7], while the governing mechanism of mitochondrial homeostasis alterations during these pathologies is largely unclear. In this special issue, S. Cao et al. provided genome-wide expression profiling of cardiomyocytes subjected to hypoxia-reoxygenation injury in an effort to uncover the roles of mitoKATP in energy homeostasis and its regulation.

We hope that the original and review articles presented in this special issue, representing the current advances in the oxidative stress-mediated ischemia-reperfusion injury, with respect to their potential impact in cellular survival pathways and therapeutic strategies, will stimulate further exploration of this important area. Despite diversity, it is our belief that the articles comprised in this special issue could represent an important advancement and contribution to improve our knowledge of the mechanisms governing reperfusion injury.


This special issue would not be possible without the great efforts of the authors and the reviewers. In this regard, we would like to thank all these people that took part in the achievement of this issue.

Zhengyuan Xia
Yanfang Chen
Qian Fan
Mengzhou Xue
Ke-xuan Liu


  1. Z. Xia, Y. Chen, Q. Fan, and M. Xue, “Oxidative stress-mediated reperfusion injury: mechanism and therapies,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 373081, 2 pages, 2014. View at: Publisher Site | Google Scholar
  2. F. Chiazza, K. Chegaev, M. Rogazzo et al., “A nitric oxide-donor furoxan moiety improves the efficacy of edaravone against early renal dysfunction and injury evoked by ischemia/reperfusion,” Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 804659, 12 pages, 2015. View at: Publisher Site | Google Scholar
  3. D. Zhao, Q. Li, Q. Huang et al., “Cardioprotective effect of propofol against oxygen glucose deprivation and reperfusion injury in H9c2 cells,” Oxidative Medicine and Cellular Longevity, vol. 2015, Article ID 184938, 8 pages, 2015. View at: Publisher Site | Google Scholar
  4. K.-X. Liu, T. Rinne, W. He, F. Wang, and Z. Xia, “Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat,” Canadian Journal of Anesthesia, vol. 54, no. 5, pp. 366–374, 2007. View at: Publisher Site | Google Scholar
  5. A. Zhang, X. Chi, G. Luo et al., “Mast cell stabilization alleviates acute lung injury after orthotopic autologous liver transplantation in rats by downregulating inflammation,” PLoS ONE, vol. 8, no. 10, Article ID e75262, 2013. View at: Publisher Site | Google Scholar
  6. L. J. Stallons, J. A. Funk, and R. G. Schnellmann, “Mitochondrial Homeostasis in Acute Organ Failure,” Current Pathobiology Reports, vol. 1, no. 3, pp. 169–177, 2013. View at: Publisher Site | Google Scholar
  7. C. H. Huang, C. Y. Chiang, R. H. Pen et al., “Hypothermia treatment preserves mitochondrial integrity and viability of cardiomyocytes after ischaemic reperfusion injury,” Injury, vol. 46, no. 2, pp. 233–239, 2015. View at: Publisher Site | Google Scholar

Copyright © 2015 Zhengyuan Xia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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