Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Table 1

Summary of Nrf2 expression, Nrf2 target expression, and Nrf2 activity in long-lived models.

Model	Tissue/cell type	Nrf2 expression	Nrf2 target expression; (NQOl, HO-1, SOD-1, etc.)	Nrf2 activity; (Nrf2-ARE binding)	Reference
Naked mole rat	Liver	↑	↑	↑	[25]
	Fibroblast	↑	↑	↑	[26]
Caloric restriction	Heart	↔	↑	N.R.	This manuscript
	CMVEC	↑	N.R.	↑	[27]
Rapamycin	SkM	↔	↔	N.R.	This manuscript
	C. elegans	↑	↑	↑	[28]
Snell	SkM	↔	↔	N.R.	This manuscript
	Heart	↔	↔	N.R.	This manuscript
	Fibroblast	↑	↑	N.R.	[29]
Crowded litter	SkM	↔	↔	N.R.	This manuscript
Humans	—	—	—	—

Arrows indicate difference in the long-lived model compared to corresponding control, with ↑ indicating “greater in the long-lived model compared to control,” ↔ indicating “no difference between long-lived model and control,” and N.R. indicating “data were not reported in the investigation.” To date, no experimental data for Nrf2 expression or activity have been reported in aged humans. CMVEC: cerebromicrovascular endothelial cells; SkM: skeletal muscle (mixed skeletal muscle: gastrocnemius, soleus, and plantaris).