Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing

Figure 3

Identification of (gender-independent) age-related KEGG pathways that are coregulated in human postmitotic skeletal muscle and nervous tissues. (a) Venn diagram comparing differentially regulated KEGG pathways during ageing of human skeletal muscle and nervous tissues; data were assessed by the StRAnGER algorithm. The green circle represents the number of KEGG pathways as derived by the combinatorial analysis of six different experiments in skeletal muscle, whereas the blue circle represents the identified KEGG pathways as derived by the analysis of the GDS707 nervous tissue related dataset. The overlapping grey area represents those KEGG pathways that are commonly affected by ageing in the two tissues. (b) Distribution of the common overrepresented KEGG pathways in tissue datasets based on their (%) enrichment score. The (%) enrichment score represents the (%) ratio of the number of appearances of a KEGG ontology term in the list of DEGs versus the number which indicates the times that this KEGG ontology term exists in the annotation file of each microarray platform.