Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing

Table 1

Age-regulated genes in human males’ skeletal muscle.

Function	Gene name	Gene description	Fold change	FDR
Glucose/lipid metabolism	H6PD	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	2.35	0.013
	ALDOA	Aldolase A, fructose-bisphosphate	0.12	0.062
	ATP5S	ATP synthase, H^+ transporting, mitochondrial Fo complex, subunit s (factor B)	0.66	0.102
	ZDHHC11	Zinc finger, DHHC-type containing 11	2.04	0.032
Signal transduction/G protein signalling	LEPR	Leptin receptor	2.31	0.021
	LGR5	Leucine-rich repeat-containing G protein-coupled receptor 5	2.34	0.126
Stress response/redox homeostasis	ADH1B	Alcohol dehydrogenase 1B (class I), beta polypeptide	2.17	0.044
	BPHL	Biphenyl hydrolase-like (serine hydrolase)	0.59	0.027
	GSTT1	Glutathione S-transferase theta 1	0.63	0.108
	GSR	glutathione reductase	0.64	0.082
	DHRS4L2	Dehydrogenase/reductase (SDR family) member 4 like 2/dehydrogenase/reductase (SDR family) member 4	0.64	0.028
	HSPA2	Heat shock 70 kDa protein 2	1.91	0.092
Cell adhesion/extracellular matrix organization	LUM	Lumican	2.03	0.097
	MFAP5	Microfibrillar associated protein 5	2.17	0.053
	FN1	fibronectin 1	1.91	0.085
Unknown function	KIAA0240	KIAA0240	2.10	0.015
	ABHD3	Abhydrolase domain containing 3	2.34	0.034
	KIAA1107	Uncharacterized protein KIAA1107	0.56	0.069
Synaptic function	LIN7C	lin-7 homolog C (C. elegans)	1.94	0.015
	LRP1B	Low density lipoprotein receptor-related protein 1B	2.08	0.057
	FCER1A	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	0.51	0.022
	MTMR3	Myotubular related protein 3	2.05	0.024
	DDN	Dendrin	2.05	0.04
Cell growth/myelination	ID4	Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	2.04	0.051
	YPEL1	Yippee-like 1 (Drosophila)	2.18	0.078
	CRIM1	Cysteine-rich transmembrane BMP regulator 1 (chordin-like)	1.96	0.094
	EMP1	Epithelial membrane protein 1	2.02	0.039
Inflammatory response	SOCS2	Suppressor of cytokine signalling 2	0.49	0.041
	TACR1	tachykinin receptor 1	0.61	0.024
Mitochondrial/translation	MRPS16	Mitochondrial ribosomal protein S16	0.51	0.036
	MRPL19	Mitochondrial ribosomal protein L19	1.92	0.015
Transcription	FRY	Furry homolog (Drosophila)	0.66	0.053
	ZFP36L2	Zinc finger protein 36, C3H type-like 2	2.02	0.015
	TET2	tet oncogene family member 2	1.9	0.091
Microtubule cytoskeleton	TUBB2A	Tubulin, beta 2A	1.9	0.043
	TNNC1	Troponin C type 1 (slow)	0.15	0.082
	TUBGCP4	Tubulin, gamma complex associated protein 4	0.61	0.025
	MAPT	Microtubule-associated protein tau	0.57	0.061
Muscle contraction	MYL1	Myosin, light chain 1	0.64	0.094
Apoptosis	DAPK3	Death-associated protein kinase 3	0.64	0.083

Shown genes are representative per functional group. Gene names by HUGO; fold changes [indicating differences in old versus young tissues (values <1 denote downregulation of the respective gene)] and statistical FDR values are indicated.