Comparative Meta-Analysis of Transcriptomics Data during Cellular Senescence and In Vivo Tissue Ageing

Table 2

Age-regulated genes in human females’ skeletal muscle.

Function	Gene name	Gene description	Fold change	FDR
Lipid metabolism	GDE1	Glycerophosphodiester phosphodiesterase 1	0.55	0.035
	FABP3	Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	0.55	0.019
	ECHDC1	Enoyl CoA hydratase domain containing 1	0.57	0.034
	REPIN1	Replication initiator 1	0.59	0.078
Signal transduction/G protein signalling	NDRG2	NDRG family member 2	0.42	0.041
	PDE11A	Phosphodiesterase 11A	1.78	0.085
	TNK2	Tyrosine kinase, nonreceptor, 2	1.52	0.016
	SMAD9	SMAD family member 9	1.72	0.070
	CNKSR2	Connector enhancer of kinase suppressor of Ras 2	0.50	0.021
	SH3BP5	SH3-domain binding protein 5 (BTK-associated)	2.12	0.022
Stress response	HSPB6	Heat shock protein, alpha-crystalline-related, B6	0.58	0.029
Cytoskeleton	SYNPO2	Synaptopodin 2	1.88	0.045
	MYOM3	Myomesin family, member 3	0.51	0.018
Proteolysis	FBXO32	F-box protein 32	1.63	0.064
	SPG7	Spastic paraplegia 7 (pure and complicated autosomal recessive)	0.52	0.031
	DNAJC1	DnaJ (Hsp40) homolog, subfamily C, member 1	1.51	0.050
	TFRC	Transferrin receptor (p90, CD71)	0.50	0.026
Cell death/apoptosis	CABC1	Chaperone, ABC1 activity of bc1 complex homolog (S. pombe)	0.36	0.053
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.58	0.038
	SCOC	Short coiled-coil protein	0.54	0.037
Transmembrane transport	SLC16A3	Solute carrier family 16, member 3 (monocarboxylic acid transporter 4)	0.50	0.011
	TMED2	Transmembrane emp24 domain trafficking protein 2	0.56	0.024
Transcription	DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.53	0.038
	PHTF2	Putative homeodomain transcription factor 2	0.54	0.045
Mitochondrial/translation	MRPL4	Mitochondrial ribosomal protein L4	0.56	0.038

Shown genes are representative per functional group. Gene names by HUGO; fold changes [indicating differences in old versus young tissues (values <1 denote downregulation of the respective gene)] and statistical FDR values are indicated.