Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging and DNA Repair Processes in Shaping the Dose-Response Curve of KBrO₃-Induced DNA Damage

Figure 4

Scavenging of KBrO₃/GSH complex reactive intermediates. (a) A scavenger was included in the model as shown. (b) and (c) Pulse exposure to KBrO₃ in the presence of a scavenger. (b) Time dependence of 8-OH-dG (green) and SSB (red) levels after pulse exposure to KBrO₃ (blue). (c) Dose-response dependence of 8-OH-dG (green) and SSB (red) at a time point shown in (a) with vertical dashed line (). Both 8-OH-dG and SSB have highly sublinear threshold-like dependence. (d) and (e). Sustained exposure to KBrO₃ in the presence of a scavenger. (d) Time dependence of 8-OH-dG (green) and SSB (red) levels after exposure to various concentrations of KBrO₃ (blue). (e) Dose-response of 8-OH-dG and SSB at is similar to that in the base model due to exhaustion of the scavenger.

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