Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats

Figure 3

PACAP aerosols reverse the bronchoconstrictive effects of AMV exposure in rat lungs. Histological analysis of hematoxylin-eosin-stained lung sections from rats exposed to vehicle (a, b), AMV aerosols alone (c, d) or followed by inhalation of PACAP aerosols (e, f). Representative photomicrographs showing the structure of a representative bronchus at low (400x; a, c, and e) and higher (1000x; b, d, and f) magnification ( for each experimental group). BL: bronchial lumen; D: epithelium desquamation; E: bronchial epithelium; M: mucus; SM: smooth muscle layer; P: pyknotic nucleus.

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