Research Article

Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats

Figure 5

PACAP reverses the decrease of the activity of antioxidant enzymes (SOD, CAT, and GPx) in AMV-exposed rat lungs. The levels of SOD (a), CAT (b), and GPx (c) activities are determined on rat lung extracts from animals exposed to vehicle only (Veh.), AMV aerosols (AMV; 5 mg/m3/h) for 15 minutes followed or not by PACAP aerosols (AMV + P38; 0.1 mM) for 10 minutes. Values are expressed as means ± SEM ( for each experimental group). , based on one-way ANOVA followed by Tukey’s multiple comparison post hoc test.
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