Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats

Table 1

Effects of PACAP on lung histomorphological parameters, airway smooth muscle layer thickness (ASMT), and bronchial lumen diameter (BLD) in AMV-induced lung toxicity. Rats received AMV aerosols (AMV; 5 mg/m³/h) for 15 minutes followed or not by PACAP aerosols (AMV + P₃₈; 0.1 mM) for 10 additional minutes. Control rats (controls) received the vehicle only. Values are expressed as means ± SEM ( = 8 for each experimental group). versus controls; ^## versus AMV in Tukey’s multiple comparison post  hoc test.

	ASMT (µm)	BLD (µm)
Controls	18.66 ± 0.35	528.67 ± 9.19
AMV	39.52 ± 0.89	107.48 ± 4.77
AMV + P38	16.76 ± 0.41^##	479.09 ± 24.82^##