Pituitary Adenylate Cyclase-Activating Polypeptide Reverses Ammonium Metavanadate-Induced Airway Hyperresponsiveness in Rats

Table 2

Effects of PACAP on lung oxidative status in AMV-induced lung toxicity. Rats received AMV aerosols (AMV; 5 mg/m³/h) for 15 minutes followed or not by PACAP aerosols (AMV + P₃₈; 0.1 mM) for 10 additional minutes. Control rats (controls) received the vehicle only. Values are means ± SEM ( = 8 for each experimental group). versus control; ^# versus AMV; ^## versus AMV in Tukey’s multiple comparison post  hoc test.

	Controls	AMV	AMV + P38
GSH (nmol/mg)	57.97 ± 1.95	26.02 ± 1.29	47.99 ± 2.84^##
GSSG (nmol/mg)	5.91 ± 0.19	8.78 ± 0.17	6.01 ± 0.43^#
GSH/GSSG	9.87 ± 0.34	2.98 ± 0.16	8.20 ± 0.37^##
MDA (nmol/mg)	0.15 ± 0.03	0.17 ± 0.02	0.16 ± 0.01
H2O2 (mmol/mg)	24.76 ± 1.80	26.43 ± 2.38	28.36 ± 2.61
NO metabolites (µmol/mg)	24.70 ± 1.08	29.99 ± 3.75	31.37 ± 2.62