Research Article
Role of Circulating miRNAs as Biomarkers in Idiopathic Pulmonary Arterial Hypertension: Possible Relevance of miR-23a
Table 1
Clinical, molecular, and biochemical features.
| | ID | Age (years) | Sex | 6MWT (m) | PAP (mmHg) | CI (L/min/m2) | PVR (WU) | VR | PGC1 RE | CYTC RE | SOD RE | TAS (mM) | GPX (nmol/min/mL/) |
| | HP1 | 45 | F | 595 | 48 | 1.7 | 12.4 | No | 2.87 | 2.45 | 4.12 | 0.21 | 70.23 | | HP2 | 75 | M | 255 | 70 | 1.8 | 11 | No | 0.34 | 0.42 | 0.24 | 0.05 | 23.76 | | HP3 | 34 | F | 554 | 35 | 2.8 | 6.2 | Yes | 67.00 | 38.50 | 7.45 | 0.28 | 119.05 | | HP4 | 58 | F | 380 | 48 | 2.2 | 12 | No | 6.07 | 5.47 | 2.29 | 0.19 | 67.89 | | HP5 | 38 | F | 450 | 38 | 3.24 | 6.1 | Yes | 8.96 | 6.95 | 26.77 | 0.15 | 91.27 | | HP6 | 63 | F | 360 | 40 | 2.1 | 8.5 | No | 3.22 | 2.59 | 4.64 | 0.25 | 85.91 | | HP7 | 64 | M | 240 | 53 | 2.3 | 7.7 | No | 0.34 | 0.48 | 0.14 | 0.04 | 20.22 | | HP8 | 66 | M | 334 | 50 | 1.8 | 8.6 | No | 1.41 | 1.01 | 0.13 | 0.11 | 45.42 | | HP9 | 60 | F | 120 | 49 | 1.7 | 18.9 | No | 0.34 | 0.08 | 0.13 | 0.02 | 24.26 | | HP10 | 55 | F | 320 | 31 | 2.5 | 7.5 | Yes | 7.76 | 8.34 | 3.47 | 0.22 | 90.85 | | HP11 | 48 | F | 534 | 59 | 1.9 | 13.6 | No | 0.33 | 0.36 | 0.17 | 0.06 | 19.21 | | HP12 | 72 | F | 280 | 65 | 2.2 | 12.5 | No | 0.22 | 0.21 | 0.50 | 0.01 | 14.34 |
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6MWT: 6-minute walk test, PAP: pulmonary arterial pressure, CI: cardiac index, PVR: pulmonary vascular resistance, WU: Wood units, VR: vascular reactivity, PGC1: peroxisome proliferator-activated receptor gamma coactivator-1-alpha, RE: relative mRNA expression, CYTC: cytochrome c, SOD: superoxide dismutase, TAS: total antioxidant status, and GPX: glutathione peroxidase.
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