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Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 872428, 17 pages
Research Article

Schisandrae Fructus Supplementation Ameliorates Sciatic Neurectomy-Induced Muscle Atrophy in Mice

1Research Institute, Bio-Port Korea INC, Marine Bio-Industry Development Center, Busan 619-912, Republic of Korea
2Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 712-715, Republic of Korea
3Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 614-052, Republic of Korea
4Laboratory of Immunobiology, Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea
5Anti-Aging Research Center and Blue-Bio Industry RIC, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea
6Department of Food and Nutrition, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea
7Department of Life Science and Biotechnology, College of Natural Sciences & Human Ecology, Dong-eui University, Busan 614-714, Republic of Korea
8Department of Biochemistry, Busan National University College of Medicine, Yangsan 626-870, Republic of Korea

Received 4 October 2014; Accepted 20 April 2015

Academic Editor: Angel Catalá

Copyright © 2015 Joo Wan Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The objective of this study was to assess the possible beneficial skeletal muscle preserving effects of ethanol extract of Schisandrae Fructus (EESF) on sciatic neurectomy- (NTX-) induced hindlimb muscle atrophy in mice. Here, calf muscle atrophy was induced by unilateral right sciatic NTX. In order to investigate whether administration of EESF prevents or improves sciatic NTX-induced muscle atrophy, EESF was administered orally. Our results indicated that EESF dose-dependently diminished the decreases in markers of muscle mass and activity levels, and the increases in markers of muscle damage and fibrosis, inflammatory cell infiltration, cytokines, and apoptotic events in the gastrocnemius muscle bundles are induced by NTX. Additionally, destruction of gastrocnemius antioxidant defense systems after NTX was dose-dependently protected by treatment with EESF. EESF also upregulated muscle-specific mRNAs involved in muscle protein synthesis but downregulated those involved in protein degradation. The overall effects of 500 mg/kg EESF were similar to those of 50 mg/kg oxymetholone, but it showed more favorable antioxidant effects. The present results suggested that EESF exerts a favorable ameliorating effect on muscle atrophy induced by NTX, through anti-inflammatory and antioxidant effects related to muscle fiber protective effects and via an increase in protein synthesis and a decrease in protein degradation.