Tiliacora triandra, an Anti-Intoxication Plant, Improves Memory Impairment, Neurodegeneration, Cholinergic Function, and Oxidative Stress in Hippocampus of Ethanol Dependence Rats
Table 2
The effect of T. triandra extract on oxidative stress markers including malondialdehyde (MDA) level and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in hippocampus.
Groups/oxidative stress markers
MDA (nmol/mg·protein)
SOD (U/mg·protein)
CAT (U/mg·protein)
GSH-Px (U/mg·protein)
Control
0.0017 ± 0.0002***
2.80 ± 0.39***
12.38 ± 0.61**
3.473 ± 0.43**
Ethanol + vehicle
0.012 ± 0.0007###
0.98 ± 0.31###
8.65 ± 1.73##
2.473 ± 0.18##
Ethanol + donepezil
0.005 ± 0.0003***
2.80 ± 0.39***
13.18 ± 1.95**
4.620 ± 0.61**
Ethanol + vitamin C
0.004 ± 0.0007***
2.80 ± 0.39***
10.91 ± 0.64*
3.013 ± 0.10
Ethanol + T. triandra 100
0.005 ± 0.0005***
1.62 ± 0.43**
12.877 ± 0.72**
4.30 ± 0.53**
Ethanol + T. triandra 200
0.004 ± 0.0005***
2.12 ± 0.27***
11.55 ± 1.09**
6.29 ± 0.52***
Ethanol + T. triandra 400
0.004 ± 0.0004***
1.56 ± 0.18**
9.31 ± 1.63
3.92 ± 0.56**
Values are expressed as means ± SEM from 6 animals in each group. ## value < 0.01 and ### value < 0.001 compared with control treated group. * value < 0.05, ** value < 0.01, and *** value < 0.001 compared with ethanol dependence rats which received vehicle.
