Antioxidants and Quality of Aging: Further Evidences for a Major Role of TXNRD1 Gene Variability on Physical Performance at Old Age

Table 3

TXNRD1 SNPs showing at least one significant association with functional parameters under a nominal level (), in the sample stratified by age class, as obtained by RobustSNP association test.

SNP	Sample	Functional parameters	-score		theop
rs4445711	Long lived	ADL	2.279	0.022 (R)	0.049
	Long lived	Walking	−2.643	0.008 (R)	0.018
rs11111979	Long lived	Walking	−2.341	0.019 (R)	0.042
rs10861203	Long lived	HG	1.985	0.047 (D)	0.099
rs1128446	Long lived	Chair stand	−2.296	0.021 (R)	0.046
	Younger controls	Chair stand	−2.157	0.030 (R)	0.064
rs7310505	Younger controls	Walking	−2.085	0.037 (A)	0.078

-score represents the -statistics for the regression analyses; is the value of the best genetic model, where R is recessive, D is dominant, and A is additive model. theop refers to the value adjusted for multiple comparisons (due to the three different tested genetic models).