Superoxide Mediates Depressive Effects Induced by Hydrogen Sulfide in Rostral Ventrolateral Medulla of Spontaneously Hypertensive Rats

Figure 5

Infusion of various depressive agents suppressed NADPH oxidase activity and superoxide production in the RVLM of SHRs. Tissue levels of superoxide anion (a) and NADPH oxidase activity (b) after infusion of aCSF (artificial cerebral spinal fluid, ), NaHS (H₂S donor, ), Apocynin (NADPH oxidase inhibitor, ), SAM (a CBS agonist, ), or Tempol (SOD mimetic, ). versus aCSF group.

(a)

(b)