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Oxidative Medicine and Cellular Longevity
Volume 2015 (2015), Article ID 950890, 7 pages
http://dx.doi.org/10.1155/2015/950890
Review Article

Anticancer Properties of Phyllanthus emblica (Indian Gooseberry)

1The Lady Davis Institute The Jewish General Hospital, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, QC, Canada H3T 1E2
2The Departments of Oncology and Experimental Medicine, McGill University, Montreal, QC, Canada H3T 1E2

Received 25 September 2014; Revised 22 December 2014; Accepted 24 December 2014

Academic Editor: Tullia Maraldi

Copyright © 2015 Tiejun Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is a wealth of information emanating from both in vitro and in vivo studies indicating fruit extract of the Phyllanthus emblica tree, commonly referred to as Indian Gooseberries, has potent anticancer properties. The bioactivity in this extract is thought to be principally mediated by polyphenols, especially tannins and flavonoids. It remains unclear how polyphenols from Phyllanthus emblica can incorporate both cancer-preventative and antitumor properties. The antioxidant function of Phyllanthus emblica can account for some of the anticancer activity, but clearly other mechanisms are equally important. Herein, we provide a brief overview of the evidence supporting anticancer activity of Indian Gooseberry extracts, suggest possible mechanisms for these actions, and provide future directions that might be taken to translate these findings clinically.