Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

Figure 6

PPARα and PGC1α immunolocalization in the neocortex of WT and Tg mice. (a) PPARα IHC in 3-, 6-, and 18-month-old WT and Tg neocortex. Immunoreactivity levels are relatively high in Tg neurons at 3 months and show a mostly cytoplasmic localization. At 18 months, IHC intensity is lower in Tg than in WT neurons. Scale bars, 30 μm. (b) PGC1α IHC in 3-, 9-, and 18-month-old WT and Tg neocortex. Consistently low staining levels are observed in Tg neurons. Scale bars, 30 μm.

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