Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer’s Disease

Figure 8

GPX1 expression and distribution in WT and Tg neocortex. GPX1 shows a strongly age- and genotype-related IHC pattern (a) consistent with WB densitometric data (b). Higher expression levels at 9 months and lower levels at 3 and 18 months are detected in Tg neocortex, as compared to WT. Values are expressed as mean ± SD. ; ; . The higher magnification micrograph (c) shows elevated immunoreactivity in glial cells surrounding and infiltrating an amyloid plaque of 18-month-old Tg neocortex. Scale bars, 40 μm.