Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel

Figure 1

AGEs-induced activation of ENaC is reversed by 0.1 mM NaHS in A6 cells. (a) The representative ENaC single-channel current recorded from A6 cells, respectively, treated with basolateral 200 μg/mL BSA (control; top trace), basolateral 200 μg/mL AGEs, apical 0.1 mM NaHS, and basolateral 200 μg/mL AGEs + apical 0.1 mM NaHS (bottom trace) for 24 h. (b) Summary plot shows that AGEs treatment significantly increased ENaC , which was reversed by H₂S treatment ( for each individual experimental set; indicates compared to control; ## indicates compared to AGEs treated cells).

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