Review Article

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease

Figure 2

Schematic representation of the effects of UCP2 downregulation within the inner mitochondrial membrane. As a consequence of the reduced UCP2 function, a lower number of protons are shifted into the matrix with a consequent increase of reactive oxygen species and dysfunction of the whole OXPHOS with decreased ATP synthesis and cellular damage.