Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Table 1

Human biomarkers and oxidative stress after ICH.

Biomarkers	Sample	Methods	Value	References
8-iso-Prostaglandin F2α	Urinary	Liquid chromatography, tandem mass spectrometry	Independent biomarker of prediction of the risk for incident stroke	[140]
8-iso-Prostaglandin F2α	Plasma	Enzyme-linked immunosorbent assay	Disease severity and clinical outcome after acute ICH associated with concentration	[101]
8-OHdG	Plasma	HPLC-electrochemical detector	Level associated with 30-day outcome after ICH	[106]
Bilirubin	Plasma	Reflectance spectrophotometry	Serum bilirubin levels were significantly elevated in the early phases in hemorrhagic stroke	[141]
Vitamin C, uric acid (UA), vitamin E, ubiquinol-10	Plasma	HPLC-electrochemical detector	Lower plasma levels of UA and higher plasma levels of others correlated with the severity of the neurological impairment after ICH	[142]
ROOH	Plasma	HPLC-electrochemical detector	Predictor of poor clinical outcome in sICH survivors	[102]
TAC, TOS	Plasma	Spectrophotometrically	TOS levels increased and TAC levels decreased in acute hemorrhagic stroke	[127]

MDA, myeloperoxidase; erythrocyte glutathione peroxidase; 8-OHdG, leukocyte 8-hydroxy-2′-deoxyguanosine; HPLC, high-performance liquid chromatography; TAC, total antioxidant capacity; TOS, total oxidant status.