Research Article

Upregulation of Heme Oxygenase-1 in Response to Wild Thyme Treatment Protects against Hypertension and Oxidative Stress

Table 3

The correlation of antioxidant enzymes activity and systemic haemodynamic parameters, with oxidative status in hypertensive () and normotensive rats ().

⁢e-CAT⁢k-SOD⁢k-CAT⁢k-GPx
WSHRWSHRWSHRWSHR

MAP0.3742
= 0.231
−0.6178
= 0.032
−0.3627
= 0.247
−0.7413
= 0.006
−0.6051
= 0.037
0.2260
= 0.480
−0.3523
= 0.261
0.7480
= 0.005
TPVR0.3559
= 0.256
−0.6041
= 0.038
0.2728
= 0.391
−0.7791
= 0.003
−0.2638
= 0.407
0.0124
= 0.969
−0.3770
= 0.227
0.5628
= 0.057
L-TBARS−0.0027
= 0.993
0.6543
= 0.021
−0.1804
= 0.575
0.7807
= 0.003
0.0896
= 0.782
−0.1624
= 0.614
0.0496
= 0.878
−0.4627
= 0.130
p-TBARS0.0818
= 0.800
−0.3587
= 0.252
−0.5557
= 0.061
−0.6479
= 0.023
0.3237
= 0.305
0.2503
= 0.433
0.2615
= 0.412
0.2261
= 0.480
k-TBARS0.6637
= 0.019
−0.2964
= 0.350
−0.0921
= 0.776
0.3710
= 0.235
−0.2610
= 0.413
−0.0555
= 0.864
−0.3946
= 0.204
−0.2397
= 0.453
BIL-D−0.4345
= 0.158
0.6818
= 0.015
−0.2737
= 0.389
0.7989
= 0.002
0.1852
= 0.564
−0.2638
= 0.407
0.3991
= 0.199
−0.6828
= 0.014

SHR: spontaneously hypertensive rats that received vehicle or thyme extract; W: Wistar rats that received vehicle or thyme extract; MAP: mean arterial pressure; TPVR: total peripheral vascular resistance; L-TBARS, p-TBARS, and k-TBARS: liver thiobarbituric acid reactive substance, plasma thiobarbituric acid reactive substance, and kidney thiobarbituric acid reactive substance; BIL-D: direct bilirubin; e-CAT and k-CAT: erythrocyte catalase and kidney catalase; k-SOD: kidney superoxide dismutase; k-GPx: kidney glutathione peroxidase. Marked correlations are significant at < 0.050.