Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways

Figure 4

Carvacrol inhibited PCa cell invasion. (a) Representative images of Transwell assay in PC-3 cells were showed. Carvacrol treatment significantly reduced the invasion of PC-3 cells (, ). () Western blot showed that carvacrol treatment for 24 h reduced MMP-2 protein expression in PC-3 cells (, ). (b) Representative images of Transwell assay in DU145 cells were showed. Carvacrol treatment significantly reduced the invasion of DU145 cells (, ). () Western blot showed that carvacrol treatment for 24 h reduced MMP-2 protein expression in DU145 cells (, ).