Propofol Suppressed Hypoxia/Reoxygenation-Induced Apoptosis in HBVSMC by Regulation of the Expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK

Figure 1

Protective effects of propofol on H/R-induced cytotoxicity HBVSMC. (a) Cell viability was assessed by CCK8 assay. Cells were exposed to hypoxic conditions. Hypoxia/reoxygenation (H/R) for 2 h, 4 h, 6 h, and 8 h. The viability of control group was defined as 100%. (b) Propofol (25, 50, and 100 M) was adopted during the entire ischemia/reperfusion phase. Cell viability was assessed. (c) HBVSMC after H/R and treatment with propofol or propofol combined with SP600125 (SP)/Everolimus (Ever.) were cultured for 1 d, 2 d, 3 d, 4 d, 5 d, and 6 d in normal conditions. Cell viability was assessed. Mean ± SD, . versus control. versus H/R group without drugs.

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