AMP-Activated Protein Kinase Attenuates High Salt-Induced Activation of Epithelial Sodium Channels (ENaC) in Human Umbilical Vein Endothelial Cells

Figure 2

Effect of high sodium on ENaC activity in HUVECs. ((a) and (b)) Representative traces of ENaC single-channel current recorded from HUVECs with and without amiloride treatment. (c) Summarized obtained from the single-channel recordings as shown in (a) and (b). The data show that calculated from amiloride group significantly decreased compared to that from control group (; indicates versus control group). ((d)–(f)) Representative traces of ENaC single-channel current recorded from HUVECs under indicated conditions. (g) Summarized obtained from the single-channel recordings as shown in (d)–(f). The data show that calculated from high NaCl group significantly increased compared to that from control group ( in each group). indicates versus control group; ## represents versus high NaCl group.