Table 2: Differential expression of genes related to thioredoxin-related thiol-disulfide enzymes and antioxidant enzymes.

GeneOld versus young
(fold-difference)
Step-up
value

Thiol-disulfide enzymes: thioredoxin-related
Prxd10.62
Prdx20.35
Prdx3Up 1.4-fold0.0074
Prdx40.20
Prdx50.29
Prdx60.40
Prdx6b0.93
Srxn10.64
Txn10.77
Txn20.79
Txnrd10.65
Txnrd20.91
Txnrd30.25
Txndc170.24
Txnip0.09

Antioxidant enzymes
Sod10.32
Sod20.17
Sod3Down 4.1-fold0.0074
Cat0.75
G6pd20.99

Fold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference. Those exceeding the cut-off threshold of 2-fold are shown in bold.
Step-up false discovery rate for the comparison between young and old cells following correction for multiple comparisons.