Differential Regulation of the Extracellular Cysteine/Cystine Redox State (E_hCySS) by Lung Fibroblasts from Young and Old Mice

Table 2

Differential expression of genes related to thioredoxin-related thiol-disulfide enzymes and antioxidant enzymes.

Gene	Old versus young; (fold-difference)	Step-up; value
Thiol-disulfide enzymes: thioredoxin-related
Prxd1		0.62
Prdx2		0.35
Prdx3	Up 1.4-fold	0.0074
Prdx4		0.20
Prdx5		0.29
Prdx6		0.40
Prdx6b		0.93
Srxn1		0.64
Txn1		0.77
Txn2		0.79
Txnrd1		0.65
Txnrd2		0.91
Txnrd3		0.25
Txndc17		0.24
Txnip		0.09
Antioxidant enzymes
Sod1		0.32
Sod2		0.17
Sod3	Down 4.1-fold	0.0074
Cat		0.75
G6pd2		0.99

Fold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference. Those exceeding the cut-off threshold of 2-fold are shown in bold.
Step-up false discovery rate for the comparison between young and old cells following correction for multiple comparisons.