Table 3: Differential expression of genes related to the extracellular matrix in primary lung fibroblasts from young and old mice. Only genes that were significantly different between old and young cells are shown.

GeneOld versus young
(fold-difference)
Step-up
value

Myofibroblast transdifferentiation
Tgfb1Up 1.6-fold0.038
Tgfb3Up 6.0-fold0.0033
Acta2Up 2.2-fold0.022
Fn1Up 1.3-fold0.0091
Col4a1Up 3.2-fold0.016
Col4a2Up 2.3-fold0.0096
Col5a2Up 1.3-fold0.048
Col11a1Up 3.5-fold0.0033
Lama3Down 1.3-fold0.023
Lama4Down 16.4-fold0.0016
Lama5Up 6.0-fold0.0014

Fold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference. Those exceeding the cut-off threshold of 2-fold are shown in bold.
Step-up false discovery rate for the comparison between young and old cells following correction for multiple comparisons.