Differential Regulation of the Extracellular Cysteine/Cystine Redox State (E_hCySS) by Lung Fibroblasts from Young and Old Mice

Table 3

Differential expression of genes related to the extracellular matrix in primary lung fibroblasts from young and old mice. Only genes that were significantly different between old and young cells are shown.

Gene	Old versus young; (fold-difference)	Step-up; value
Myofibroblast transdifferentiation
Tgfb1	Up 1.6-fold	0.038
Tgfb3	Up 6.0-fold	0.0033
Acta2	Up 2.2-fold	0.022
Fn1	Up 1.3-fold	0.0091
Col4a1	Up 3.2-fold	0.016
Col4a2	Up 2.3-fold	0.0096
Col5a2	Up 1.3-fold	0.048
Col11a1	Up 3.5-fold	0.0033
Lama3	Down 1.3-fold	0.023
Lama4	Down 16.4-fold	0.0016
Lama5	Up 6.0-fold	0.0014

Fold-difference in expression in old fibroblasts relative to the expression in young fibroblasts is shown for all genes with a significant difference. Those exceeding the cut-off threshold of 2-fold are shown in bold.
Step-up false discovery rate for the comparison between young and old cells following correction for multiple comparisons.