Oxidative Medicine and Cellular Longevity / 2016 / Article / Fig 4

Research Article

Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1

Figure 4

Effects of berberine and sirtinol treatment on post-MI/R cardiac function. Normal SD rats were exposed to BBR treatment (200 mg/kg/d for 2 weeks) in the absence or presence of sirtinol (Stnl, 2 mg/kg/d for 1 week) and then subjected to myocardial ischemia reperfusion (MI/R) operation. Echocardiographic measurement was carried out after 24 hr of reperfusion. (a) Representative M-mode images by echocardiography. (b) Left ventricular ejection fraction (LVEF). (c) Left ventricular fractional shortening (LVFS). The results are expressed as the mean ± SEM, /group. versus Sham group, versus MI/R + V group, and versus MI/R + BBR group.

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