Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1

Figure 7

Effects of berberine and sirtinol treatment on inflammation response in normal rat heart. Normal SD rats were exposed to BBR treatment (200 mg/kg/d for 2 weeks) in the absence or presence of sirtinol (Stnl, 2 mg/kg/d for 1 week) and then subjected to myocardial ischemia reperfusion (MI/R) operation. Cardiac oxidative stress level was measured after 6 hr of reperfusion. (a) Myocardium IL-6 level. (b) Myocardium TNF-α level. (c) Serum TNF-α level. (d) Myocardium MPO activity. The results are expressed as the mean ± SEM, /group. versus Sham group, versus MI/R + V group, and versus MI/R + BBR group.

(a)

(b)

(c)

(d)