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Oxidative Medicine and Cellular Longevity
Volume 2016 (2016), Article ID 1730750, 12 pages
Review Article

Gasotransmitters in Gametogenesis and Early Development: Holy Trinity for Assisted Reproductive Technology—A Review

1Laboratory of Reproductive Medicine of Biomedical Center, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 1655/76, 323 00 Pilsen, Czech Republic
2Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University in Prague, Alej Svobody 1655/76, 323 00 Pilsen, Czech Republic
3Team Régulation des Signaux de Division, UMR 8576 CNRS, Université Lille 1, Sciences et Technologies, FR 3688 CNRS, 596 55 Villeneuve d’Ascq Cedex, France
4Institute of Animal Science, Pratelstvi 815, 104 00 Praha Uhrineves, Czech Republic

Received 29 April 2016; Accepted 3 July 2016

Academic Editor: Michael D. Pluth

Copyright © 2016 Jan Nevoral et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Creation of both gametes, sperm and oocyte, and their fusion during fertilization are essential step for beginning of life. Although molecular mechanisms regulating gametogenesis, fertilization, and early embryonic development are still subjected to intensive study, a lot of phenomena remain unclear. Based on our best knowledge and own results, we consider gasotransmitters to be essential for various signalisation in oocytes and embryos. In accordance with nitric oxide (NO) and hydrogen sulfide (H2S) physiological necessity, their involvement during oocyte maturation and regulative role in fertilization followed by embryonic development have been described. During these processes, NO- and H2S-derived posttranslational modifications represent the main mode of their regulative effect. While NO represent the most understood gasotransmitter and H2S is still intensively studied gasotransmitter, appreciation of carbon monoxide (CO) role in reproduction is still missing. Overall understanding of gasotransmitters including their interaction is promising for reproductive medicine and assisted reproductive technologies (ART), because these approaches contend with failure of in vitro assisted reproduction.