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Oxidative Medicine and Cellular Longevity
Volume 2016, Article ID 1735841, 11 pages
Research Article

Amla Enhances Mitochondrial Spare Respiratory Capacity by Increasing Mitochondrial Biogenesis and Antioxidant Systems in a Murine Skeletal Muscle Cell Line

1Institute for Health Science, MIKI Corporation, 3-12-4, Naruohama, Nishinomiya, Hyogo 663-8142, Japan
2Department of Medicine, Division of Endocrinology and Metabolism, Shiga University of Medical Science, Tsukinowa, Seta, Otsu, Shiga 520-2192, Japan

Received 26 December 2015; Revised 25 March 2016; Accepted 4 May 2016

Academic Editor: Thomas Kietzmann

Copyright © 2016 Hirotaka Yamamoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Amla treatment stimulated mitochondrial bioenergetics function. To explore an active integrant in Amla, Amla extract was separated by reversed-phase chromatography to obtain a polyphenol-rich fraction (a mixture of polyphenols corresponding to what is present in the Amla fruit) and a polyphenol-poor fraction (a mixture of the constituents of Amla extract without polyphenols). We analyzed mitochondrial function and found that the effect of Amla treatment was due to the polyphenol-rich fraction. These results indicated that the polyphenols were the functional components responsible for the observed effects.

  1. Supplementary Material