Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK1/2-CREB-Bcl-2 Signaling Pathway in Diabetic Rats

Figure 6

(a) Western blotting was performed to evaluate the expression levels of p-ERK1/2 and p-CREB. Brain tissues were extracted at 0 h, 1 h, 3 h, 6 h, and 24 h after MCAO. The phosphorylation of ERK1/2 (b) and CREB (c) peaked at 1 h. Data are expressed as mean ± SD; rats/group ( versus 0 h; versus 1 h).

(a)

(b)

(c)