Hypochlorite-Modified Albumin Upregulates ICAM-1 Expression via a MAPK–NF-κB Signaling Cascade: Protective Effects of Apocynin

Figure 5

Relationships between ERK1/2, , and NF-κB. HUVECs were preincubated with SN50, U0126, or SB203580 for 1 h before stimulation with 200 mg/L HOCl-alb. The activation of ERK1/2 and (a) and the proportions of NF-κB/p65 in the nucleus and cytoplasm (b) were determined with western blotting. Data are expressed as the means ± SD of three independent experiments. ANOVA, in (a) and (b); versus control; versus the HOCl-alb group.

(a)

(b)